Survival analysis of myopic regression after small-incision lenticule extraction and femtosecond laser-assisted laser in situ keratomileusis for low-to-moderate myopia

Session Details

Session Title: Small Lenticule Extraction I

Session Date/Time: Sunday 15/09/2019 | 08:00-10:00

Paper Time: 08:30

Venue: Free Paper Forum: Podium 1

First Author: : Z.Jihong CHINA

Co Author(s): :    S. Li   W. Gu   Y. Gao   L. Wu   X. Guo                 

Abstract Details

Purpose:

A Cox proportional hazards model was proposed to identify predictive factors of myopic regression after subjects who had underwent small-incision lenticule extraction (SMILE) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) for 12 months result.

Setting:

Beijing Aier-Intech Eye Hospital, Beijing, China.

Methods:

Retrospective comparative study. All patients recruited had a manifest spherical equivalent from -0.50 to -6.0D myopia. Refractive outcomes were recorded at 1day,1week, 1, 3, 6, and 12 months postoperatively. A Cox proportional hazards model was used to evaluate the impact of the two methods of surgery and other covariates on postoperative myopic regression. Myopic regression was defined as residual myopia < -0.50 D and a > 0.50 D shift toward myopia during the follow-up visits.

Results:

The study enrolled 1697 patients (1697 right eyes).1108 patients in FS-LASIK group, 589 patients in SMILE group. At 12 months, the survival rates were 83.01% in FS-LASIK group and 80.88% in SMILE group. For two methods, significant predictors of myopic regression included corneal curvature Kmax (HR=0.873, P =0.0113, 95%CI: 0.786-0.97 ), preoperative manifest spherical equivalent (HR=0.90, P = 0.0467, 95%CI: 0.811-0.998), optical zone (OZ) (HR=0.068, P <0.001, 95%CI: 0.026-0.181), the probability of postoperative myopic regression with a small-incision lenticule extraction and femtosecond laser-assisted laser in situ keratomileusis were similar(P =0.4012) in multivariate analysis by Cox proportional hazards model during12 months.

Conclusions:

12 months postoperatively, small-incision lenticule extraction (SMILE) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) had similar risk of myopic regression; Kmax, preoperative manifest SE and optical zone were predictors of myopic regression for low to moderate myopia.

Financial Disclosure:

None