Posters

Precorneal tear film stability in patients with diabetes mellitus

Poster Details

First Author: M.Vasovic SERBIA

Co Author(s): M. Radenkovic   G. Stankovic-Babic                 

Abstract Details

Purpose:

Diabetus mellitus is frequent metabolic disorder. It is characterized by prolonged hyperglycemia. Diabetes could be insulin dependent (IDDM) or independent (NIDDM), type I or type II. Diabetic complications are find in anterior or posterior eye segment. May be different, but most patients experience Ocular Surface Disease related problem. OSD is multifactorial disorder due to age, environment, surgery, metabolic or eye disease. Hyperglycemia, periphery neuropathy, microvasculopathy, systemic hyperosmotic disturbances disrupt Lacrimal Functional Unit as risk factors for diabetes-associated OSD. Tear hyperosmolarity and tear film instability caused by LFU and ocular surface dysfunction are key factors in OSD.

Setting:

Investigation was performed in Health Center and Eye Clinic (Clinical Center) in Nis from March 2016 to September 2018 to detect precorneal tear film instability in diabetic patients in comparison to health individuals without additional therapy and glaucoma drug treated patients.

Methods:

Retrospective-prospective analysis in 547 diabetic patients, 140 medicamentous treated glaucoma (OAG/XFG type) patients and 90 healthy individuals. Demographyc characteristics was analysed. Standard ophthalmologic examination was carried out (slit lamp and Tear Break-Up Time) to test precorneal tear film stability. Statistical analysis was performed in SPSS18.

Results:

A statistically significant difference was found, women were more likely to have dry eye problem in 73% (399 women). OSD highest percentage in long-term diabetic was in the elderly population, over 67% (372 patients). Juvenile diabetes did not manifest OSD problem (37 patients under 18 years of age (7%)). Reduced TBUT 5-10s in 55% of patients (301 patients), less than 5s had 15% (82 patients), more than 10s had other patients. In glaucoma group: <5s(7,14%), 45,71% with 5-10s and >10s in 47,14%. Healthy individuals: <5s(1,11%), 17,78% with 5-10s and >10s in 81,11%.

Conclusions:

In this work we wanted to point out that there are an increasing number of diabetic patients and unrecognised dry eye problem. Highest percentage of tear film instability manifested trough reduced TBUT was in diabetic group, than in glaucoma group due to topical drug and benzalkonium chloride, and lowest in healthy ones. TBUT is simple and not time consuming test that can be performed in routine work and gives us a lot of information. Therefore is recommended as screening procedure.

Financial Disclosure:

None