The protective effect of heparin and influence on the corneal structure regeneration

Session Details

Session Title: Moderated Poster Session: Refractive
Session Date/Time: Saturday 16/02/2019 | 14:00-15:00
Paper Time: 14:00
Venue: Poster Area


First Author: E.Mrukwa-Kominek POLAND
Co Author(s): W. Lubon  J. Janiszewska-Salamon  K. Jadczyk-Sorek           

Abstract Details

Purpose:

Heparin is an organic chemical compound that naturally has many functions in the human body, primarily related to antithrombotic activity. It is most often administered as a drug, for many systemic diseases, related to abnormal circulation in the human body. Heparin was also used as a substance as a component of drops and ophthalmic ointments used in pathologies related to the surface of the eyeball In the prospective observational study it was decided to check and analyze data on the efficacy, tolerance and possible side effects of the used ophthalmic preparations with heparin, confirming the possible benefits of their use

Setting:

Department of Ophthalmology, Katowice Division, Medical University of Silesia, Poland

Methods:

Twenty people (6 women, 14 men) with corneal erosion due to blunt trauma (9 patients) or with corneal foreign body (11 patients) who came to ophthalmological accident & emergency department were included in the study. The standard medical treatment was applied (fluoroquinolone antibiotic) and adjuvant treatment in the form of drops and eye ointments containing heparin with the recommendation of use: eye drops 4 x daily (HyloParin, Ursapharm, Germany - 1 mg / ml sodium hyaluronate + 1300 IU / ml sodium heparin), eye ointment 2 x daily (ParinPOS, Ursapharm, Germany - composition 1300 IU / ml sodium heparin).

Results:

After 5-7 days (from the order of ophthalmic medication) the symptoms in all (100%) patients have significantly decreased. Regeneration of the corneal epithelium was observed and still present only a small amount of epithelial defects. Treatment resulted in improvement of cornea condition. Tests - Schirmer's and T-BUT confirmed the efficacy of applied treatment, parameters were within the population standard (> 15 mm / 5min for the Schirmer test without anesthesia and > 10 sec for the T-BUT test). The average of patients for the Schirmer test without anesthesia was 15.5 mm / 5min, average TBUT test was 11 sec.

Conclusions:

Eye drops and ointments containing heparin were an effective additional treatment of corneal erosion after removing a foreign body or blunt trauma

Financial Disclosure:

None