Evaluation of ocular higher-order aberrations in first-degree relatives of patients with keratoconus

Session Details

Session Title: Cornea & Miscellaneous
Session Date/Time: Friday 15/02/2019 | 10:30-12:30
Paper Time: 10:48
Venue: Room MC3

First Author: A.Eslampoor IRAN
Co Author(s): S. Zarei Ghanavati  M. Namdari  -. -           

Abstract Details

Purpose:

To evaluate the ocular high order aberrations, in first-degree relatives of kertoconus patients and to compare these data with normal population.

Setting:

In this prospective comparative study 210 eyes from105 family members of 28 keratoconus patients and 210 normal eyes of 105 control subjects were enrolled.Family members should be at least 15 years of age, have no comorbid diseases and should have no sign of KCN regarding examination and imagings.

Methods:

A complete ophthalmic examination was done for all patients, including best-corrected visual acuity(BCVA) using a Snellen chart , cycloplegic refraction(FCR) ,slit-lamp biomicroscopy, , intra-ocular pressure and dilated fundus examination. Corneal topographic analysis was performed on both eyes of each study participant, using a TMS-4 videokeratoscope (Tomey Corporation, Nagoya,Japan)and Orbscan IIz (Bausch & Lomb,Rochester, NY) .Wavefront analysis was performed with ZyWave aberrometer (Bausch & Lomb, Technolas,NY ). Each eye was evaluated 3 times. Zernike coefficients were calculated up to the fifth order in a 6mm optical zone.Statistical testing was performed using SPSS (version21; SPSS, Inc, Chicago, IL).

Results:

The study included 61 (58.1%) female and 44 (41.9%) male subjects with mean age of 31 years (range, 15–50 years) and 105 age-sex matched controls.In 14 of 105 first-degree relatives (13.33%) of keratoconus patients, keratoconus was diagnosed whom were excluded from study. Root mean square (RMS) of all HOAs including vertical trefoil, vertical coma, horizontal coma, horizontal trefoil, quadrifoil and 4th order spherical aberrations were significantly greater in the relative group than controls when we analyzed absolute value of data in both eyes and each eye separately.

Conclusions:

Higher order aberrations are significantly greater in family members of keratoconus as compared to controls. In addition, due to a higher prevalence of KCN and KCN suspects in the relatives of patients with KCN, refractive surgeons need to ask specifically regarding a family history of keratoconus and in positive cases careful screening must be considered for subtle topographic, tomographic and aberrometric abnormalities before any keratorefractive surgery. Significant amount of HOAs should be considered a caution for refractive surgeon for doing more evaluation before keratorefractive surgery.

Financial Disclosure:

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