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Combining corneal tomograghy and biomechanical parameters for detection of mild forms of ectasia

Session Details

Session Title: Imaging II

Session Date/Time: Monday 07/10/2013 | 16:30-18:00

Paper Time: 17:10

Venue: Main Lecture Hall (Ground Floor)

First Author: : F.Faria Correia PORTUGAL

Co Author(s): :    I. Ramos   B. Lopes   R. Correa   A. Luz   R. Ambrósio Jr  

Abstract Details

Purpose:

To improve diagnosis of Form Fruste Keratoconus using combined tomographic and biomechanical data provided by Scheimpflug imaging.

Setting:

Instituto de Olhos Renato Ambrósio - Rio de Janeiro, Brazil

Methods:

Pentacam HR (Oculus, Wetzlar, Germany) and Corvis ST (Oculus, Wetzlar, Germany) were performed in 119 eyes with normal corneas (group N) and 15 eyes with Form Fruste Keratoconus (group FFKC). Topometric, tomographic and biomechanical indices were analyzed. Fisher’s linear discriminant analysis (LDA) was performed to find a linear combination of these parameters, which best separates the two groups. The AUROC curve was also calculated, and pairwise comparisons were performed using DeLong’s method.

Results:

AUROC for BAD-D and for ART Max. were superior than the best topometric and elevation indices (p<0.05). Biomechanical parameters that had the highest value of AUROC were the first and second applanation length (0.876 and 0.827, respectively), but were not statistically significant compared to the BAD-D (p=0.836 and p=0.362, respectively). AUROC for the best combination of tomographic and biomechanical parameters provided by Fisher’s LDA was 0.985 (sensitivity and specificity of 100% and 86.6%, respectively), and was superior than the best tomographic and biomechanical indices (p<0.05).

Conclusions:

Isolated parameters provided by corneal tomography and biomechanics do not allow an efficient separation between N and FFKC. Combining tomography and biomechanical data increase the ability to detect mild forms of ectasia.

Financial Interest:

... receives non-monetary benefits from a company producing, developing or supplying the product or procedure presented.