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Effect of platelet lysate on corneal epithelial healing after PRK

Session Details

Session Title: Surface Ablation I

Session Date/Time: Sunday 06/10/2013 | 08:00-09:30

Paper Time: 09:12

Venue: Main Lecture Hall (Ground Floor)

First Author: : F.Velasco MEXICO

Co Author(s): :    J. Vidaurri-Leal              

Abstract Details

Purpose:

To evaluate the effect of platelet lysate eye drops on corneal epithelial healing after photorefractive keratectomy (PRK).

Setting:

Centro de Oftalmologia San Jose, Monterrey, NL Mexico

Methods:

Twenty eigth eyes of 14 patients treated with PRK for myopia were enrolled in this prospective, randomized study. Fourteen eyes were treated postoperatively with standard topical therapy and 14 with platelet lysate eye drops. Postoperatively, patients were examined daily until the epithelium healed. The velocity of resurfacing was recorded. Corneal clarity, visual acuity, and refraction were evaluated during the 3-month postoperative period.

Results:

Complete epithelial healing was observed starting at postoperative day 3 in 46% of eyes in the platelet lysate group and 14% of eyes in the control group. At day 4, 98% and 72% of eyes in the platelet lysate and control groups, respectively, had healed. Five days after PRK, 100% of eyes treated with platelet lysate and 92% of control eyes achieved complete epithelial healing. In the control group, 98% of eyes healed at day 6 and all eyes completed healing at day 7. The difference in healing time was statistically significant (P<.001). No statistically significant differences were noted for haze prevalence, uncorrected distance visual acuity, and spherical equivalent refraction after treatment between groups (P>.05). No side or complications effects were reported during the study.

Conclusions:

platelet lysate accelerates epithelial healing after PRK and could be used as additional treatment in circumstances of delayed healing.

Financial Interest:

NONE