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The intraoperative application of bevacizumab to decrease postoperative corneal haze during laser surface ablation

Session Details

Session Title: Surface Ablation II

Session Date/Time: Tuesday 08/10/2013 | 16:30-18:00

Paper Time: 17:33

Venue: Main Lecture Hall (Ground Floor)

First Author: : J.Kim SOUTH KOREA

Co Author(s): :    I. Song   M. Kim   H. Tchah   C. Choi     

Abstract Details

Purpose:

Our previous study using rat model showed that intraoperative bevacizumab administration decreased central corneal haze and apoptotic keratocyte number after surface ablation (Invest Ophthalmol Vis Sci. 2012; 53:7645–7653). We attempt to apply bevacizumab intraoperatively to decrease the postoperative corneal hazy during surface ablation.

Setting:

Tertiary training hostpital

Methods:

12 eyes out of 6 patients who underwent surface ablation were included. The eyes were randomly assigned to PRK with intraoperative topical 1.25% bevacizumab (Avastin; Roche Diagnostics, Basel, Switzerland) application and the fellow eye was treated with 0.02% mitomycin C (MMC) application. Immediately after surface ablation, a sponge soaked with bevacizumab or MMC placebo was placed onto each exposed corneal bed in the both eyes. The time length of eye contact with bevacizumab or MMC (10 to 50 seconds) was determined according to the ablation depth. Postoperative information regarding BCVA, UCVA, IOP, refraction, and slit lamp photography was obtained at 7 days and 1 month after surgery.

Results:

There were no significant differences between two groups in postoperative BCVA, UCVA, IOP, refraction, and postoperative haze for up to 1 month after surgery.

Conclusions:

Bevacizumab can be a safe alternative to MMC during surface ablation to prevent postoperative corneal haze.

Financial Interest:

NONE