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Correlation of corneal biomechanics with corneal morphology in keratoconus

Session Details

Session Title: Corneal biomechanics

Session Date/Time: Tuesday 08/10/2013 | 08:00-10:30

Paper Time: 09:48

Venue: Elicium 1 (First Floor)

First Author: : B.Ekinci Koktekir TURKEY

Co Author(s): :    B. Bozkurt   U. Kamis   R. Unuvar   S. Okudan     

Abstract Details

Purpose:

To evaluate the corneal biomechanical parameters and their correlations with corneal topography and central corneal thickness (CCT) in keratoconus.

Setting:

Selcuk University Faculty of Medicine Department of Ophthalmology

Methods:

Thirty-eight eyes of 38 keratoconus patients and 22 eyes of 22 age- and sex-matched controls with healthy corneas were included into this comparative study. All patients underwent a complete ophthalmic examination including measurement of corneal biomechanics (corneal hysteresis (CH) and corneal resistance factor (CRF)) with Reichert Ocular Response Analyzer. Corneal topographic parameters (K1, K2, Kmax) (OPD- Scan II, Nidek, Japan) and CCT measurements (Lenstar LS 900, Haag Streit, Japan) were performed additionally in patients with keratoconus. Mann Whitney U test was performed for the comparison of parameters in keratoconus and healthy eyes and Spearman correlation coefficient was calculated to find out the relationships between the parameters (SPSS 16.0 Inc.). A p value < 0.05 was accepted as statistically significant.

Results:

The mean CH and CRF were significantly lower in the keratoconus group (8.29±2.06 and 9.02±11.82, respectively) compared to healthy controls (10.68±2.05 and 10.53±2.53, respectively) (p<0.001). In the keratoconus group, significant correlations were found between CH and Kmax (Spearman rho= -0.49), CH and CCT (rho= 0.71), CRF and Kmax (rho= -0.66) and CRF and CCT (rho= 0.59) (all, p<0.001). Moreover, there was a significant negative correlation between Kmax and CCT (rho=-0.67, p<0.001).

Conclusions:

Corneal biomechanics is deteriorated in eyes with keratoconus parallel with the severity of the disease.

Financial Interest:

NONE