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To compare the utility of routine microbiology versus DNA macrochip (XCyton) in the management of postoperative endophthalmitis

Session Details

Session Title: Inflammation

Session Date/Time: Tuesday 08/10/2013 | 16:30-18:00

Paper Time: 17:14

Venue: Auditorium (First Floor)

First Author: : R.Morris INDIA

Co Author(s): :    D. Bachu   D. Rathinasabapathy   D. Venkatapathy        

Abstract Details

Purpose:

To compare the etiologic identification rates using routine microbiology to those with DNA Macro chip (XCYTON) and treatment outcomes resulting from the additional use of the DNA Macro chip in cases with postoperative endophthalmitis.

Setting:

Aravind Eye Hospital , Coimbatore , India.

Methods:

A Prospective, randomized trial included 19 patients with acute post operative endophthalmitis. Conventional management was followed with initial tap for microbiology followed by injection or surgery as needed. Subsequent treatment was guided by DNA Macro chip in all the patients. Parameters analysed were microbiological identification rates, management , treatment outcomes and complications.

Results:

DNA Macrochip (XCYTON) had 94.7 % identification rate compared to 36.8 %with routine microbiology. All patients were managed based on XCYTON results. 78.9 % received intravitreal antibiotics, 57.8 % underwent core vitrectomy, 42.1% received intravitreal antifungals and 26.3 % recieved intravitreal steriods.An improvement of mean baseline visual acuity 1.72(0.81) logmar to a mean final visual acuity 0.54(0.65) logmar was noted (P-0.0003). 5.26% of patients had cystoid macular edema and epiretinal membrane each. 10.5 % had retinal detachment.

Conclusions:

Early and increased microbiological yield from DNA Macrochip (XCYTON) led to improved treatment outcome , informed early decision making and rational antibiotic use.

Financial Interest:

NONE