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Ultrasonic circular cyclo-coagulation in patients with primary open-angle glaucoma: a multicenter clinical trial

Session Details

Session Title: Glaucoma

Session Date/Time: Monday 07/10/2013 | 17:00-18:34

Paper Time: 17:10

Venue: Elicium 2 (First Floor)

First Author: : F.Aptel FRANCE

Co Author(s): :    P. Denis   J. Rouland   J. Nordmann   Y. Lachkar   J. Renard   E.

Abstract Details

Purpose:

We aimed to evaluate the efficacy and safety of the Ultrasonic Circular Cyclo Coagulation (UC3) procedure.

Setting:

Nine French glaucoma centers.

Methods:

Prospective non-comparative interventional clinical study. Forty-two eyes of 42 patients with primary open-angle glaucoma (POAG), intraocular pressure (IOP) > 21 mmHg, an average of 1.65 failed previous surgeries and an average of 3.2 hypotensive medications were insonified with a therapy probe comprising 6 piezoelectric transducers. The 6 transducers were activated, 18 patients (group 1) were treated with a 4 seconds exposure time for each shot and 29 patients (group 2) with a 6 seconds exposure time. Complete ophthalmic examinations were performed before the procedure, and at 1 day, 1 week, 1, 2, 3, 6 and 12 months after. Primary outcomes were surgical success (defined as IOP reduction from baseline ? 20% and IOP > 5mmHg) at the last follow-up visit, and vision-threatening complications. Secondary outcomes were mean IOP at each follow-up visits compared to baseline, medication use, complications, and re-interventions.

Results:

IOP was significantly reduced in both groups (p<0.05), from a mean preoperative value of 29.4 ± 4.7 mmHg in group 1 and 29.1 ± 7.8 mmHg in group 2 to a mean value of 17.0 ± 4.2 mmHg in group 1 and 17.9 ± 4.1 mmHg in group 2 at last follow-up. Success (IOP reduction >20%) was achieved in 10 of 18 (60%) eyes of the group 1 and in 21 of 29 (72%) eyes of the group 2 at last follow-up. Four patients were ret-treated. No major intra- or post-operative complications occurred.

Conclusions:

Ultrasonic Circular Cyclo Coagulation seems to be an effective and well-tolerated method to reduce intraocular pressure in patients with POAG.

Financial Interest:

... receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented, ... travel has been funded, fully or partially, by a company producing, developing or supplying the product or procedure presented, ... research is funded, fully or partially, by a company producing, developing or supplying the product or procedure presented