First Author: G.Kontadakis GREECE
Co Author(s): A. Pallikaris V. Kankariya G. Kymionis
Purpose:
To present corneal confocal microscopy (CCM) findings in a series of non-related patients with pre-Descemet corneal dystrophy (PDCD) and in a patient prior to and after photorefractive keratectomy (PRK).
Setting:
: Institute of Vision and Optics, University of Crete
Methods:
A 28-year old man that presented for laser vision correction and subsequently underwent photorefractive keratectomy (PRK) with adjuvant application of mitomycin-C for correction of myopia, a 50 year old man and a 31 year old woman were clinically diagnosed with pre-Descemet corneal dystrophy (PDCD) on slit lamp microscopic evaluation. Subsequently, all patients were evaluated by means of CCM. The 28-year old man was examined prior to and 1 year after PRK. Both his parents were also evaluated by slit lamp biomicroscopy and CCM. The parents of the other two patients were clinically evaluated with slit lamp biomicroscopy.
Results:
In all the patients, corneal confocal microscopy revealed highly reflective stromal particles and pleomorphic structures that included particles in the deep stroma, immediately anterior to the Descemet membrane extending up to 30-60μm from endothelium. The patient, that underwent PRK, had uneventful postoperative course and demonstrated similar findings postoperatively as in the preoperative examination. Both his parents had no clinical or CCM findings reminiscent of PDCD. No evidence of PDCD was observed clinically in the parents of the other patients.
Conclusions:
Corneal confocal microscopy is an effective method to confirm diagnosis of PDCD. Specific pattern of CCM findings appears to be related with non-related sporadic cases of PDCD in this series of patients. No adverse events of PRK related to the dystrophy were observed
Financial Disclosure:
No
