Session Title: Cornea
Session Date/Time: Sunday 05/02/2012 | 08:30-11:00
Paper Time: 08:42
Venue: Hall 1
First Author: : S.Moolani INDIA
Co Author(s): : K. Rao S. Dhawan S. Natarajan
Purpose:
To evaluate the safety, efficacy of riboflavin-ultraviolet A irradiation (UVA) corneal cross-linking and present refractive changes induced by the treatment in cases of keratoconus.
Setting:
Department of Cornea and Refractive Surgery,
Aditya Jyot Eye Hospital Pvt. Ltd.,
Mumbai, India
Methods:
The study includes 39 eyes of 22 patients with keratoconus with an average keratometric (K) reading less than 54 D and minimal corneal thickness greater than 400 microns. The corneal epithelium was removed manually and the cornea was soaked with riboflavin eye drops for 30 minutes followed by exposure to UVA radiation for 30 minutes. During the follow-up period, uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), manifest refraction, slit lamp examination and topographic changes were recorded at the first week, first month, 3 and 6 months. RESULTS There was statistically significant improvement of UCVA from a preoperative mean of 0.12 ± 0.06 (range 0.04-0.4) to a postoperative mean of 0.16 ± 0.05 (range 0.1-0.3) (P < 0.05). The preoperative mean K of 49.26 ± 2.37 D (range 47.70-51.25) changed to 48.29 ± 2.46 D (range 45.53-50.08). This decrease in K readings was statistically significant (P < 0.05). All eyes developed minimal faint stromal haze that cleared in 38 eyes within 1 month. Progression of the original disease was not seen in any of the treated eyes within 6 months of follow-up.
Conclusions:
Riboflavin-UVA corneal cross-linking is a safe and promising method for keratoconus. Larger studies with longer follow up are recommended.
Financial Disclosure:
No
