Session Title: Cornea
Session Date/Time: Sunday 05/02/2012 | 08:30-11:00
Paper Time: 08:36
Venue: Hall 1
First Author: : D.Muller UNITED STATES
Co Author(s): : J. Marshall P. Hersh M. Friedman
Purpose:
To determine the role of oxygen and the photochemical kinetic mechanisms of corneal cross-linking with riboflavin
Setting:
Laboratory studies were undertaken at Avedro, Waltham, MA and the Institute of Ophthalmology, University College, London
Methods:
Theoretical modeling and computer analysis of the photochemical kinetics of corneal cross-linking with riboflavin was developed using constants determined through both literature search and experiment. The results of the modeling and analysis were compared to oxygen concentration measurements of a dissolved oxygen fiber optic sensor under corneal flaps of a known depth during corneal cross-linking under various irradiance and temperature conditions. RESULTS It was found that oxygen is rapidly depleted during the first several seconds during corneal cross-linking with riboflavin and after 10-15 minutes slowly begins to replenish itself. The results of the computer analysis and the various experiments were highly correlated.
Conclusions:
The results of the modeling suggest that the photochemical kinetics of corneal cross-linking with riboflavin are governed by a predominantly Type I photochemical mechanism where direct interaction between riboflavin triplets and corneal proteins lead to corneal cross-linking and that the Type II photochemical mechanism involving singlet oxygen plays a more minor role than previously thought.
Financial Disclosure:
... has significant investment interest in a company producing, developing or supplying product or procedure presented, ... travel has been funded, fully or partially, by a company producing, developing or supplying the product or procedure presented, ... is employed by a for-profit company with an interest in the subject of the presentation
