Session Title: Cornea
Session Date/Time: Sunday 05/02/2012 | 08:30-11:00
Paper Time: 08:30
Venue: Hall 1
First Author: : D.Muller UNITED STATES
Co Author(s): : J. Marshall P. Hersh M. Friedman
Purpose:
To elucidate the importance of proper characterization of UV/Riboflavin corneal absorption to optimize and customize corneal cross-linking
Setting:
Laboratory studies were undertaken at the Institute of Ophthalmology, University College London, Hersh Vision Institute Teaneck, NJ and at Avedro, Waltham, MA
Methods:
Computer modeling analysis using experimentally determined diffusion rates combined with various UVA intensity and dose was conducted to determine the three dimensional cross-linking dosage which would be expected in actual in vivo clinical practice of corneal cross linking. Diffusion rates of various riboflavin mixtures and concentrations were experimentally determined using both porcine and human corneas. RESULTS It was found that the UVA/Riboflavin absorption could be customized to have different absorption profiles as a function of depth within the cornea. These UVA/Riboflavin absorption profiles are modified by varying Riboflavin formulation, pre-soak time, UVA intensity and dose. Proper selection of these parameters allows for increased cross-linking of the anterior stroma and less UVA absorption in the posterior stroma near the endothelium.
Conclusions:
The effects of corneal cross-linking can be significantly improved and customized by choosing the proper concentration of riboflavin, pre-soak times, UVA intensity and dose. In so doing, the safety and efficacy of the procedure will be improved and patient selection criteria can be expanded to adjust for thinner corneas.
Financial Disclosure:
... gains financially from product or procedure presented, ... is employed by a for-profit company with an interest in the subject of the presentation, ... has significant investment interest in a company producing, developing or supplying product or procedure presented
