Session Title: Cataract I
Session Date/Time: Friday 03/02/2012 | 10:30-12:30
Paper Time: 11:57
Venue: Hall 1
First Author: : C.Choi KOREA, REPUBLIC OF
Co Author(s): :
Purpose:
To investigate the toxic anterior segment syndrome(TASS) in experimental rabbit model
Setting:
Experimental rabbit model
Methods:
benzalkonium chloride(BAC), Talc powder, proteolytic enzyme detergent(Cidezyme®, johnson and Johnson Inc.), Antiseptics(Cidex®, johnson and Johnson Inc.), Antibiotics ophthalmic ointment, Tryphan blue and Indocyanine green(ICG) dye were injected and irrigated with balanced salt solution in anterior chamber of each eye. Anterior segment photography, ultrasound pachymetry, Inflammatory cytokine assay(PGE2 assay ParameterTM, R&D systems, Inc., Inflammatory cytokines Multi-analyte ELISA Array kitTM Qiagen Inc.), and scanning electron microscopy on iris were done. RESULTS Each causative material has different inflammatory reaction. Talc powder caused anterior chamber inflammation and membrane formation predominantly. But Antiseptics led to corneal edema predominantly. Especially Benzalkonium chloride, Proteolytic enzyme detergent, tryphan blue and ICG caused both inflammatory reaction of anterior chamber and corneal edema. And High inflammatory cytokine level of aqueous humor was observed in those cases. Antibiotic ophthalmic ointment rarely caused inflammation and corneal edema.
Conclusions:
TASS occurrence may be associated with the causative materials such as BAC, talc power, proteolytic enzyme, Antiseptics, ICG and tryphan blue. But each material showed different inflammatory reaction.
Financial Disclosure:
No
