First Author: C.Kanonidou GREECE
Co Author(s): E. Kanonidou V. Konidaris N. Ziakas L. Papazisis
Purpose:
To analyse the spectrum of gram-negative ocular isolates along with their in vitro susceptibility to fluoroquinolones from 2004 to 2010. The widespread use of fluoroquinolones against ocular infections has lead to the emergence of antibiotic-resistant microorganisms and to a steadily decrease of their in vitro potency.
Setting:
Department of Ophthalmology, General Hospital of Veria, Veria, Greece.
Methods:
A retrospective audit of the medical records of patients treated for keratitis and endophalmitis during 2004-2010 was carried out. Adequate specimens (cornea scrapings, intraocular fluids) were collected prior to antibacterial therapy. The minimum inhibitory concentrations (MICs, ?g/ml) against second- (ciprofloxacin), third- (levofloxacin) and fourth-generation fluoroquinolones (moxifloxacin) were determined by Vitek 2 (Biomerieux, France).
Results:
Out of 135 ocular isolates, 36 (27%) were gram-negative. The most commonly isolated gram-negative bacteria were Pseudomonas spp. (50%) followed by E. coli (14%) and Enterobacter spp. (13%). No significant changes in the prevalence of gram-negative infections and to the spectrum of bacterial isolates over time were observed. All Pseudomonas spp. isolates were equally susceptible to ciprofloxacin, levofloxacin and moxifloxacin.
Conclusions:
The number of ocular infections caused by gram-negative bacteria remained stable over time. All fluoroquinolones tested presented the same in vitro effectiveness against the most common ocular isolate. These laboratory results should be correlated with clinical treatment/outcome studies. FINANCIAL DISCLOSURE?: No
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