Detection of viruses in aqueous humor of patients with Fuchs’ uveitis syndrome (FUS)

Poster Details

First Author: S.Murthy INDIA

Co Author(s):    S. Sabhapandit   V. Sangwan           

Abstract Details

Purpose:

To determine the association of various infectious agents in Fuchs’ uveitis syndrome by polymerase chain reaction of serum and aqueous.

Setting:

L.V Prasad Eye Institute, Hyderabad, India

Methods:

Prospective, case-control study of Fuchs uveitis (n=25), anterior uveitis (n=15) and normals (n=50), conducted between September 2009 to February 2010. Patients were included based on pre-defined inclusion and exclusion criteria for all the three groups. Patients with posterior segment pathology and diabetes mellitus were excluded. Polymerase chain reaction of aqueous humour and serum for rubella, herpes simpex virus (HSV), cytomegalo virus (CMV), varicella zoster virus (VZV) and toxoplasma was done using standard primers.

Results:

Ninety patients were enrolled in the study in three groups, which were comparable for age, gender and laterality of ocular involvement. All patients had diffuse keratic precipitates in the FHU group, with iris nodules noted in one case each in uveitis and FUS group. PCR was negative for detection of VZV, CMV, toxoplasma and rubella in all three groups, both from serum and aqueous. Only one eye had PCR positive for HSV in the FUS group but this was not statistically significant (p=0.42).

Conclusions:

In our study, there was no association of infectious agents with Fuchs’ uveitis. The exact etiology in this disease still remains answered. FINANCIAL DISCLOSURE?: No