First Author: M.Peyman MALAYSIA
Co Author(s): H. Razmjoo M. Kooshanmehr A. Peyman
Purpose:
This study aims to compare 1% and 2% concentrations of Mitomycin-C (MMC) after photorefractive keratectomy (PRK) in terms of recovery of visual acuity
Setting:
University of Malaya Eye Research Center, Isfahan Eye Research Center
Methods:
85 patients enrolled in this prospective study. In each subject one eye randomly assigned to group 1 and the second eye to the group 2. Patients underwent surface ablation for treatment of myopia and myopic astigmatism with tissue saving protocol of a Technolas 217z excimer system. In group 1 after ablation Mitomycin-C 1% (0.1mg/ml) solution applied to cornea for 30 seconds, and in group 2 we used Mitomycin-C with concentration of 2% (0.2mg/ml) for 30 seconds before irrigation of the surface and placement of bandage lens. Ocular examination was done before the procedure as well as 1 week, 1, 2, 3 and 6 month after PRK.
Results:
Mean spherical equivalent refraction of attempted correction with PRK was -3.16±1.72 diopters (D) (Mean ± Standard deviation). The best corrected visual acuity and mean spherical equivalent refraction were statistically similar for both groups at the latter postoperative time points at 1 week, 1, 3 and 6 month (P>0.05). No statistically difference in uncorrected visual acuity was noted between two groups within the 6 month postoperatively (P>0.05).
Conclusions:
Both concentrations of Mitomycin-C appear to be equally effective on visual recovery. Probably using lower concentration of this agent may help to decrease the risk of ocular toxicity. FINANCIAL DISCLOSURE?: No
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