Comparison of posterior capsule opacification development with 3-piece and 1-piece sharp-edge optic hydrophobic acrylic intraocular lenses: data of five-year prospective clinical trial

Poster Details

First Author: R.Zemaitiene LITHUANIA

Co Author(s):                  

Abstract Details

Purpose:

To evaluate and compare the impact of different design acrylic hydrophobic sharp-edge optic intraocular lenses (IOL) on posterior and anterior lens capsule opacification (PCO and ACO).

Setting:

Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences

Methods:

Fifty six eyes of 50 patients having a standard uncomplicated phacoemulsification procedure for age-related cataract were included in a prospective clinical study: 27 eyes with a 3-piece acrylic hydrophobic (AcrySof, MA3OBA) IOL and 29 eyes with a 1-piece acrylic hydrophobic (AcrySof, SA3OAL) IOL. Patients were examined at the slit lamp, visual acuity was determined, and standartized digital retroillumination images of the posterior capsule were taken at 5-year follow-up. The PCO values in the entire IOL optic area and in the central 3-mm optic zone were assessed using a photographic image-analysis system (EPCO2000). The intensity of opacification of anterior capsule leaf on the intraocular lens anterior surface was assessed subjectively. Capsulotomies performed by means of neodymium-yttrium-aluminum-garnet (Nd:YAG) laser were recorded. The eyes treated with Nd: YAG laser capsulotomy were excluded from the EPCO 2000 evaluation.

Results:

There were no significant differences in best corrected visual acuity, grade of ACO density and capsulorrhexis/optic overlapping between IOL types during five-year after surgery. There were no significant differences in the PCO values (mean (SD)) either in the entire IOL optic area (3-piece: 0.27 (0.24); 1-piece: 0.16 (0.19)) or in the central 3-mm optic zone (3-piece: 0.14 (0.17); 1-piece: 0.06 (0.11)) comparing the groups at 5-year follow-up. In 9 (33.3%) of 27 eyes with a 3-piece acrylic IOL and 5 (17.2%) of 29 eyes with a 1-piece acrylic IOL had Nd: YAG laser capsulotomy (P=0.13).

Conclusions:

Long-term (5-year) follow-up after cataract surgery has shown no difference existence in ACO and PCO development between 3-piece and 1-piece acrylic hydrophobic intraocular lenses. The effect of these foldable lenses in preventing posterior capsule opacification is a result of rectangular, sharp-edged optic design and hydrophobic acrylic biomaterial. FINANCIAL DISCLOSURE?: No