First Author: H.Razmjoo IRAN
Co Author(s): A. Peyman M. Kooshanmehr
Purpose:
to compare effectiveness of Mitomycin-C with two different concentrations of 1% and 2% for prevention of corneal haziness after myopic photorefractive keratectomy (PRK)
Setting:
Isfahan Eye Research Center, Isfahan University of Medical Sciences
Methods:
85 patients enrolled in this prospective study. In each subject one eye randomly assigned to group 1 and the second eye to the group 2. Patients underwent surface ablation for treatment of myopia and myopic astigmatism with tissue saving protocol of a Technolas 217z excimer system. In both groups alcohol used for epithelial removal and similar post-op antibiotic and corticosteroid drops prescribed. In group 1 after ablation Mitomycin-C 1% (0.1mg/ml) solution applied to cornea for 30 seconds, and in group 2 we used Mitomycin-C with concentration of 2% (0.2mg/ml) for 30 seconds before irrigation of the surface and placement of bandage lens.
Results:
at 1 month post-operative visits 8.2% of patients in group 1 had grade 2 corneal haze compared to 4.7% in group 2. In months 2, 3, and 6 visits 7.1%, 0%, 0% patients in group 1, and 3.5%, 0%, 0% patients in group 2 had grade 2 of cornea haziness, respectively. No patients in each group had grade 3 or more score of haziness in every group. Although patients seemed to have marginally less corneal haze with 2% concentration of Mitomycin-C the difference between groups was not statistically significant (P>0.05 for all comparisons).
Conclusions:
There is no difference between 1% and 2% concentrations of Mitomycin-C regarding prevention of corneal haze formation after myopic photorefractive keratectomy. FINANCIAL DISCLOSURE?: No
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