First Author: S.Chen CHINA
Co Author(s): Y. Feng Q. Wang
Purpose:
To evaluate the safety, efficacy, and predictability of IntraLase (Abbott Medical Optics) femtosecond laserassisted compared to microkeratome-assisted myopic LASIK.
Setting:
Eye Hospital of Wenzhou Medical College, China.
Methods:
A comprehensive literature search of
Cochrane Library, PubMed, and EMBASE was conducted to identify relevant trials comparing LASIK with IntraLase femtosecond laser to LASIK with microkeratomes for the
correction of myopia. Meta-analyses were performed on the primary outcomes (loss of >/=2 lines of corrected distance visual acuity [CDVA], uncorrected distance visual
acuity [UDVA] 20/20 or better, manifest refraction spherical equivalent [MRSE] within +/-0.50 diopters [D],final refractive SE, and astigmatism), and secondary outcomes (flap thickness predictability, changes in higher
order aberrations [HOAs], and complications).
Results:
Fifteen articles describing a total of 3679 eyes were identifi ed. No significant differences were
identified between the two groups in regards to a loss of >/=2 lines of CDVA (P=.44), patients achieving UDVA 20/20 or better (P=.24), final UDVA (P=.12), final mean refractive SE (P=.74), final astigmatism (P=.27), or changes in HOAs. The IntraLase group had more
patients who were within +/-0.50 D of target refraction (P=.05) compared to the microkeratome group, and
flap thickness was more predictable in the IntraLasegroup (P<.0001). The microkeratome group had more
epithelial defects (P=.04), whereas the IntraLase group had more cases of diffuse lamellar keratitis (P=.01).
Conclusions:
According to the available data, LASIK with the IntraLase femtosecond laser offers no significant benefits over LASIK with microkeratomes in regards to safety and efficacy, but has potential advantages in predictability. FINANCIAL DISCLOSURE?: No
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