First Author: S.Linke GERMANY
Co Author(s): T. Ceyrowski J. Steinberg K. Kuhnert G. Richard T. Katz
Purpose:
To quantify the difference in corneal thickness between the central and thinnest point (?CCT-TPCT) and the distance between the center of the cornea and its thinnest point (TPCT vector length), and to explore the impact of general (age, sex) and ophthalmic (refractive state, keratometry, ocular side) parameters.
Setting:
Multicenter, retrospective, cross-sectional study.
Methods:
Medical records of 8054 eyes of 4027 refractive surgery candidates were reviewed. Measurements were taken with a Scheimpflug imaging system (Pentacam). Corneas classified as abnormal were excluded (n = 108). The correlation between ?CCT-TPCT and TPCT vector length and the variables age, sex, refractive state (spherical equivalent and cylinder), Kmax and simK were assessed. Right and left eyes were analyzed separately. Spearman rank correlations, t-tests, ANOVA, ANCOVA and multiple regression models were used.
Results:
?CCT-TPCT was higher in left eyes of myopes (3.03 ± 2.29 µm) and hyperopes (4.97 ± 3.19 µm) compared to myopic (2.39 ± 2.28 µm) and hyperopic (4.77 ± 3.97 µm; for all P <0.05) right eyes, and ?CCT-TPCT was higher in hyperopes than myopes (P <0.001). TPCT vector length was 0.62 ± 0.28 mm for the right and 0.69 ± 0.24 mm for the left eye (P <0.001). TPCT vector length tended to increase with advancing age. Age had the strongest independent effect on TPCT vector length in myopic [F(3,3577)=21.483, P <0.001, ?²= 0.018] and hyperopic [F(3,440)=4.255, P = 0.006, ?² = 0.028] right eyes. No difference was observed between male and female subjects (P >0.05) and between Kmax subgroups. The correlations between ?CCT-TPCT and TPCT vector length were strong (r >0.8; P <0.001).
Conclusions:
Due to significant differences found, normative data on ocular side, refractive state and age should be incorporated into ?CCT-TPCT and TPCT vector length reference values. FINANCIAL DISCLOSURE?: No
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