First Author: O.Richoz SWITZERLAND
Co Author(s): F. Hafezi
Purpose:
To study the UVA absorption rate of various antibiotics and their potential effect on the efficacy of CXL for infectious corneal melting.
Setting:
CXL is used in therapy-resistant infectious corneal melting. The absorption rate of moxifloxacin 0.5 % and ofloxacin 0.3 % in the UVA range (365 nm) is significant higher when compared to riboflavine 0.1 %. Other classes of antibiotics do not absorb UVA significantly. Quinolones may interfere with the efficacy of a CXL treatment for infectious keratitis and should be stopped prior to CXL with respect to their half life time.
Methods:
UVA light absorption at 365 nm was determined for ofloxacin 0.3 %, moxifloxacin 0.5 %, and other commonly used antibiotics.
Results:
Moxifloxacin 0.5 % and ofloxacin 0.3 % showed high UVA absorption rates whereas other antibiotics do not absorb UVA significantly.
Conclusions:
The UVA absorption rate of quinolones is significant. Quinolones can interfere with the efficacy of a CXL treatment for infectious keratitis and should be stopped prior to CXL with respect to their half life time. FINANCIAL DISCLOSURE?: No
Please wait while information is loading.
