Biomechanical properties of human anterior lens capsule and atomic force microscopy

Poster Details

First Author: K.Tsaousis GREECE

Co Author(s):    P. Karagiannidis   V. Karagkiozaki   S. Logothetidis   L. Lamprogiannis   S. Dimitrakos   I. Tsinopoulos

Abstract Details

Purpose:

To appraise the biomechanical properties of anterior lens capsule through atomic force microscopy.

Setting:

Laboratory of " Thin Films - Nanosystems & Nanometrology (LTFN)" Physics Department Aristotle University of Thessaloniki, Greece

Methods:

Human anterior lens capsule taken during phacoemulsification cataract surgery and was studied with an atomic force microscopy. For the purpose of the study, five different indentation loading forces were applied in near areas of the specimen. Silicon cantilevers were used with a force constant in the range of 1-2 N/m. Data exported through NOVA software and analyzed according the Hertz model to acquire the Young Modulus. Force-Distance curves were acquired by applying a load of 2, 5, 10, 20 and 30 nN.

Results:

The values of Young’s modulus for the different curves depending on the loading force (2, 5, 10, 20 and 30 nN) were 367, 9; 277,7; 286,7; 328,6 and 279,6 kPA respectively.

Conclusions:

Atomic Force microscopy is a powerful tool of nanotechnology and is valuable for studying the biomechanical properties of tissues as human anterior lens capsule. Determination of Young’s modulus of the anterior lens capsule is quite independent from the loading force concerning the examined range. FINANCIAL DISCLOSURE?: No