Corneal neovascularization, the most important risk factor for corneal allograft rejection which leads to blindness, can be prevented with a topical antioxidant from green tea

Poster Details

First Author: L.Gutierrez MEXICO

Co Author(s):    J. Flores   V. Sanchez   A. Rodriguez        

Abstract Details

Purpose:

Epigallocatechin 3–Galato is an antioxidant and a flavonoid produced as a secondary metabolite by the camellia sinensis plant " green tea" wich, suppresses a wide variety of inflammatory cytokines and angiogenic cytokines similar to those involved in corneal neovascularization

Setting:

: Asociacion para evitar la ceguera en Mexico.

Methods:

Corneal neovascularization was induced in rabbits using sodium hydroxide were applied drops of the flavonoid epigallocatechin 3 - gallate 4 times daily for 7 days at different doses. We assessed inflammation and neovascularization through clinical, histopathological, and with inmunohistochemistry techniques.

Results:

The group of rabbits that received the epigallocatechin 3-gallate at a dose of 1 mg / ml showed minimal or no inflammation and neovascularization both clinical, histopathological, and with the inmunohistochemistry techniques used Anti- monoclonal antibodies anti – VEGF, anti- 8-oHdG, T.U.N.E.L)

Conclusions:

Epigallocatechin 3-gallate by its antioxidant, antiproliferative, antiangiogenic and anti-inflammatory antimestastasic properties make it an important target of study. FINANCIAL DISCLOSURE?: No