First Author: I.Tsinopoulos GREECE
Co Author(s): L. Lamprogiannis K. Tsaousis P. Kavatzikidou E. Pavlidou S. Dimitrakos S. Logothetidis
Purpose:
To study two opacified intraocular lenses (IOLs) , a 3-piece hydrophobic lens and an hydrophilic lens, with the use of Scanning Electron Microscopy and determine the location and composition of the opacification; to determine whether depositions can be removed with treatment with trypsin.
Setting:
Anterior Eye Department,2nd University Ophthalmological Clinic, Aristotle University of Thessaloniki,Greece;
Laboratory for Thin Films Nanosystems and Nanometrology, Department of Physics, Aristotle University of Thessaloniki,Greece
Methods:
An opacified hydrophobic 3-piece acrylic IOL was explanted from a 64 year old patient 10 years after uneventful cataract surgery and 2 years after posterior vitrectomy with SF6 gas which was performed to treat retinal detachment. The lens was studied with SEM. An opacified hydrophilic IOL that was explanted from a 58 year old parient 5 months after uneventful cataract surgery was cut in three pieces that were treated with trypsin(0,25%)-EDTA solution. The pieces were examined with SEM.
Results:
The opacifications were located , on both lenses, on their surface. They consisted mainly of calcium (Ca) and phosphorus (P), presumably hydroxyapatite, which is in accordance with previous studies. Treatment with trypsin-EDTA removed a great part of the opacifications.
Conclusions:
Opacification of hydrophobic IOLs is a complication which is rarely described,in comparison with the opacification of hydrophilic IOLS, and can be reasonably attributed to the posterior vitrectomy with the use of SF6 gas. Treatment with trypsin-EDTA appears to be a promising field of research for the in vivo treatment of patients with opacificated Intraocular Lenses, without having to remove the lens. However, the issues of the necessary concentration of trypsine for a full removal of the depositions and the possible toxicity need to be addressed prior to applying this treatment. FINANCIAL DISCLOSURE?: No
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