First Author: N.Kim SOUTH KOREA
Co Author(s): J. Yoon
Purpose:
To compare the intraocular pressure (IOP) in parents and their offspring in Korea.
Setting:
Family-based cohort study.
Methods:
This study examined the data for 2,083 subjects (627 mothers, 627 father, 431 sons, and 398 daughters) obtained from the Korean National Health and Nutrition Examination Surveys conducted between 2008 and 2009. The IOP values were measured with a Goldmann applanation tonometer. The correlations and heritability for intraocular pressure between family members were calculated. The individuals were stratified into 2 groups, those with and without a high IOP of ?16mmHg, based on the superior quartile IOP value of the entire study population. The Odds ratio for high IOP was evaluated in those with high IOP in one and both parents compared with subjects whose parents did not have high IOP. The relationship between parental systemic disease and IOP in their offspring was also investigated. The analyses were adjusted for confounding variables including age, sex, refractive error, body mass index, blood pressure, fasting glucose, and total cholesterol.
Results:
Mean IOP in the right and left eye was 13.90 ± 2.733 and 13.90 ± 2.756, respectively. Correlations in parent-offspring and sibling pairs for IOP were 0.257 and 0.254, respectively and were all statistically significant. Compared with the subjects whose parents did not have a high IOP, the odds ratio (95% CI) for a high IOP in subjects with one and two parents with a high IOP was 2.05 (1.52 - 2.96) and 4.49 (2.88 - 7.02), respectively. The IOP was not associated with parental diabetes mellitus, hypertension, obesity or metabolic syndrome.
Conclusions:
The IOP showed a significant heritable tendency from parents to their offspring in an isolated Asian population. The risk of a high IOP increased significantly in subjects with a parental high IOP. FINANCIAL DISCLOSURE?: No
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