Higher order aberrations and amblyopia: comparison of higher order aberration profiles of normal and amblyopic eyes in children with idiopathic amblyopia

Poster Details

First Author: G.Prakash INDIA

Co Author(s):    A. Mazhari   N. Sharma   R. Saxena        

Abstract Details

Purpose:

To evaluate the higher order aberrations as a possible cause for idiopathic amblyopia.

Setting:

All India Institute of Medical Sciences

Methods:

In this cross sectional observational trial, 17 patients of previously diagnosed idiopathic amblyopia underwent wavefront analysis on Zyoptix platform (Bausch and Lomb)

Results:

The mean age was 9.2±2.8 years. The higher order aberrations (HOA) were analyzed using stepwise regression analysis to find out the predictive value for each HOA term by all other HOA terms .Maximum difference in the R-squared values between amblyopic and fellow eyes was seen with coma-like and trefoil-like aberrations (third order and fifth order terms). Third order : horizontal coma (R2=0.3 for fellow versus 0.0 amblyopic), vertical trefoil (R2 = 0.8 for fellow versus 0.4 for amblyopic), horizontal trefoil (R2=0.3 for fellow versus 0.8 for amblyopic); Fifth order : secondary vertical coma (R2=0.9 for fellow versus 0.8 for amblyopic), secondary horizontal coma (R2=0.4 for fellow versus 0.5 for amblyopic), and secondary vertical trefoil (R2=0.4 for fellow versus 0.7 for amblyopic), secondary horizontal trefoil (R2=0.6 for fellow versus 0.9 for amblyopic).

Conclusions:

It seems a strong possibility that a subset of ‘idiopathic' amblyopia may be associated with loss of symmetry in wavefront patterns of the two eyes. FINANCIAL DISCLOSURE?: No