Posters

Correlations between macular pigment optical density, serum lipid profile and central macular thickness

Poster Details

First Author: A. Loo MALAYSIA

Co Author(s):    R. Sudarno   V. Subrayan                 

Abstract Details

Purpose:

To determine the relationship, if any, between macular pigment optical density (MPOD) and serum lipid profile (namely total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL)), and central macular thickness.

Setting:

Department of Ophthalmology, Faculty of Medicine, University of Malaya, Kuala Lumpur.

Methods:

This is a comparative cross-sectional study performed in a single institution. 210 volunteers who met the inclusion criteria were included in this study. Subject’s MPOD was measured using Macula Pigment Screener II, (MPSII, by Electron Technology). Central macular thickness was measured by Spectral Domain Cirrus Optical Coherence Tomography (OCT), Cirrus (Model 4000, Carl Zeiss Meditec). For both MPOD and OCT, information from both eyes were recorded. For all subjects, fasting serum lipids were taken. The data were analysed using Microsoft® Excel (Version 15.12.3(150724) ©2015 Microsoft), SPSS (IBM® SPSS®Statistics Version 2.2), and R(version 3.2.1; R Core Team 2015)

Results:

There was significant positive correlation between MPOD and central macular thickness, (r=0.42, p<0.01) and significant negative correlation between MPOD and BMI (r=-0.23, p<0.01). There was no significant correlation between MPOD and serum lipid profile.

Conclusions:

Our study showed significant positive correlation between MPOD and central macular thickness. Further study is needed to look at the detailed structure of the fovea and its relationship with MPOD. Our study also found significant negative correlation between MPOD and BMI, suggesting that reduction in BMI may increase the density of macula pigment, which in turn may be helpful in preventing ARMD.

Financial Disclosure:

NONE