Posters

The affect of colchicine and M694V mutations on the ocular surface in patients with Familial Mediterranean fever (FMF)

Poster Details

First Author: M. Kosker TURKEY

Co Author(s):    M. Acar   N. Arslan   A. Dogan   M. Alp   C. Ozisler   C. Gurdal     

Abstract Details

Purpose:

To assess the affect of colchicine and M694V mutations on the ocular surface in patients with FMF.

Setting:

Patients with FMF referred to Genetic Diagnostic Center in Diskapi Yildirim Beyazit Training and Research Hospital from June 2013 to June 2015 were included in the study.

Methods:

Ocular surface changes were evaluated using ocular surface disease index questionnaire (OSDI), Schirmer-I test, break-up time (BUT), corneal fluorescein, Lissamine green staining and mebiography.

Results:

Mean OSDI score and mebomian gland drop out was more in group 1 than in group 2 (p=0.03 and p=0,04 respectively). Mean shirmer test values were less in group 1 (20,82±9,94mm) than in group 2 (26,03±8,28 mm) (p<0.01). The mean BUT was 6,53±3,7 and 11,64±2,97 in groups 1 and 2, respectively (p<0,0001). Mean fluorescein corneal staining was 2,78±2,89 and 0,19±0,4 in groups 1 and 2 (p<0,0001). Ocular surface test results were similar between the new diagnosed FMF patients who were not on colchicine (26 patients) and previously diagnosed FMF patients who were on colchicine (62 patients). Ocular surface test results between FMF patients with M694V homozygote mutation (16 patients) and those without M694V homozygote mutation (72 patients) were similar (p>0.05).

Conclusions:

Uncontrolled inflammation triggered by Mediterranean fever gene mutations might lead to dry eye disease through both tear evaporation caused by mebomian gland drop out and aqueous deficiency caused by the decrease of tear production. But it has been detected that having M694V mutations and the use of colchicine did not have a major affect on the ocular surface.

Financial Disclosure:

NONE