Posters

Diagnostic value of retinal ganglion cell complex and peripapillary retinal nerve fiber layer thickness measurement in early glaucomatous damage

Poster Details

First Author: S. Pinchuk UKRAINE

Co Author(s):    M. Karliychuk   O. Baryska                 

Abstract Details

Purpose:

to evaluate the diagnostic value of retinal ganglion cell complex (GCC) (composed of the macular nerve fiber layer and ganglion cell layer with the inner plexiform layer) and peripapillary retinal nerve fiber layer (RNFL) thickness measurement in early glaucomatous damage.

Setting:

Bukovinian State Medical University, Chernivtsi, Ukraine Center of Modern Ophthalmology ‘Vash Zir’, Chernivtsi, Ukraine

Methods:

The study involved 25 healthy eyes and 23 eyes with preperimetric glaucoma. There were no significant differences in visual acuity and visual field damage (according to central 30-2 test, Twinfield, Oculus, Germany) between healthy eyes and eyes with preperimetric glaucoma. Macular GCC and peripapillary RNFL thickness were measured by frequency-domain OCT (RTVue-100, Optovue, USA. RNFL 3,45, and GCC Protocols). Sequence of diagnostic value of morphometric parameters for preperimetric glaucoma diagnostics included parameters of GCC (Global loss volume (GLV), GCC Average, GCC Inferior), RNFL nasal, inferior/nasal, superior/nasal, temporal, inferior/temporal and superior/ temporal thickness, and RNFL average thickness.

Results:

The average visual field Mean Deviation was -0,87 ± 1,16 dB for the healthy eyes, and -1,08 ± 1,18 dB for the eyes with preperimetric glaucoma. There were significant differences between the preperimetric glaucoma and healthy eyes for GCC and for almost all peripapillary RNFL thickness parameters (p<0,05), except for the nasal RNFL (3, 4, 9, and 10 o’clock zones). Mean regional macular GCC was most severely thinned in the inferior perifoveal region, where its thickness was <67,0% of its normal thickness in 19 (82,6%) eyes with preperimetric glaucoma.

Conclusions:

It was established that the most sensitive parameters in diagnosis of early glaucomatous damage are GCC parameters: GLV, GCC Average, GCC Inferior. Our results suggest that accurate measurement of GCC parameters and peripapillary RNFL thickness by frequency-domain OCT and a comparison of the results with normative database can improve detection of early glaucomatous damage.

Financial Disclosure:

NONE