Posters

Secondary glaucoma due to CMV anterior uveitis

Poster Details

First Author: C. Altan TURKEY

Co Author(s):    B. Basarir   B. Satana   F. Ozcelik   I. Yilmaz   M. Taskapili        

Abstract Details

Purpose:

To describe the diagnostic and therapeutic management of cytomegalovirus (CMV) anterior uveitis associated with secondary glaucoma.

Setting:

Beyoglu Eye Training and Research Hospital

Methods:

Five patients with unilateral, chronic or recurrent uveitis associated with secondary glaucoma and positive polymerase chain reaction analysis of the aqueous humour for CMV were enrolled. Specific antiviral treatment was initiated in all cases and the level of ocular inflammation and intraocular pressure (IOP) were evaluated during the follow up.

Results:

The mean age of three men and two women were 33,4 years. Anterior unilateral uveitis with coin-like keratic precipitates was observed without corneal scars, posterior synechiae, flare or fibrin and posterior segment involvement in all cases. Uveitis was chronic in two cases and recurrent in three cases. Acyclovir was previously used in two cases without efficacy. Refractory glaucoma was observed in all patients with a median intraocular pressure of 40,4 (30-60) mmHg. Four patients responded initially to topical ganciclovir therapy; one patient required systemic valganciclovir treatment in addition to antiinflamatory and antiglaucoma therapy. Ocular inflammation and glaucoma were controlled medically in all cases and relapses did not occur during follow-up. The mean IOP was 14 (12-17) mmHg at last visit.

Conclusions:

CMV infection should be considered in all cases with recurrent or chronic iridocyclitis presenting with coin-like keratic presipitates and secondary glaucoma. Glaucoma and uveitis can only be controlled with spesific anti-viral theraphy in addition to antiinflammatory and antiglaucoma treatment.

Financial Disclosure:

NONE