Posters

Accelerated collagen cross-linking of cornea (CXL) with isotonic riboflavin solution in progressive keratoconus in North Indian population: short-term results

Poster Details

First Author: A. Mazhari INDIA

Co Author(s):    R. Shukla   P. Chakarpani   P. Mahajan   R. Kairati           

Abstract Details

Purpose:

To evaluate the refractive and clinical outcomes of 10 minutes protocol of accelerated corneal collagen cross-linking (CXL) with the help of topography, pachymetry and high definition OCT after collagen cross-linking in eyes with progressive keratoconus in north Indian population.

Setting:

Cornea and refractive surgery services, Indira Gandhi Eye Hospital and Research Centre, Lucknow, India

Methods:

54 eyes underwent epithelium off accelerated collagen cross-linking by instilling isotonic riboflavin 0.1% solution containing 20% dextran every 3 minutes for 30 minutes before, and during the 10 minutes of ultraviolet A irradiation (9 mW/cm2) by Lightmed-Lightlink crosslinking system. We measured the UDVA, CDVA, refraction, topographic values (Atlas 9000 topographer, Carl Zeiss), pachymetry values (Visante ASOCT, Carl Zeiss) and demarcation lines (HDOCT, Carl Zeiss ) at 1 week and at 1, 3, and 6 months after surgery and these were compared with preoperative findings.

Results:

Mean UDVA and CDVA (in decimal) were 0.18±0.18 and 0.53±0.21 preoperatively which progressively improved to 0.23±0.19 and 0.54±0.22 respectively at 6 months. Preoperatively mean spherical refraction was -3.30±3.11 DS and cylindrical refraction was -3.19±2.23 DC which improved to -2.97±3.12 DS and - 2.61±1.94 DC respectively. Mean Kmax preoperatively was 50.54±4.27 D which changed to 48.03±5.14 D at 6 months. Mean minimum corneal thickness (MCT) preoperatively was 449.50±45.43 μm and it was 432.20±49.48 μm at 6 months. Mean demarcation line one week postoperatively was 290±14.24 μm which got stabilized to 259.67±23.11 μm at 6 months.

Conclusions:

Ectasia due to keratoconus was arrested by accelerated CXL in our cases with stabilization or improvement of mean UDVA, CDVA, refraction and Kmax after 6 months of follow-up. There were improvements in topography indices, suggesting a more regular corneal surface. We also studied the effect of CXL on corneal stroma by analysing the demarcation lines during the follow-ups.

Financial Disclosure:

NONE