Posters

Changes of corneal biomechanics in thyroid orbitopathy: does it affect IOP estimation?

Poster Details

First Author: Z. Pniakowska POLAND

Co Author(s):    A. Klysik   R. Gos   P. Jurowski              

Abstract Details

Purpose:

To determine the relevance of the objective parameters addressing the altered biomechanical properties of cornea for glaucoma monitoring in patients with mild or moderate thyroid associated orbitopathy (TAO), and in healthy individuals.

Setting:

Department of Ophthalmology and Visual Rehabilitation, The University Clinical Hospital of Military Medical School- The Veterans Central Hospital, Lodz, Poland

Methods:

Twenty-five patients with TAO (group 1) and 25 healthy adults (group 2) were included to the study. Both groups were of a similar age and the ratio women:man. For each patient, the following parameters of both eyes were measured with ocular response analyzer (ORA): corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann correlated intraocular pressure (IOPg) and corneal compensated intraocular pressure (IOPcc). In both groups participating in our study, all measurements were performed within minutes to reduce the diurnal effects.

Results:

The mean age in group 1 was 56±11y and 64±11y in group 2. CH correlated negatively with IOPg in group 1 (r2=0.10, P<0.05). IOPg strongly correlated with IOPcc in both groups (group 1: r2=0.79, P<0.0001; group 2: r2=0.85, P<0.0001). There was a positive correlation between CRF and IOPg in group 1 (r2=0.12, P<0.05) and in group 2 (r2=0.31, P<0.0001). Statistical analysis revealed no correlation between CRF and IOPcc in group 1 (r2=0.009, P>0.05) as well as in group 2 (r2=0.04, P>0.05). CRF mean value in group 2 (11.51±1.72 mm Hg) was higher than in group 1 (10.85±1.45 mm Hg), (P<0.05). There was also a correlation between CRF and CH in both populations: group 1: (r2=0.58, P<0.0001), group 2: (r2=0.41, P<0.0001).

Conclusions:

Biomechanical parameters of a cornea, as quantified by CH and CRF, and measured together with IOPcc, precisely reveal glaucoma staging in TAO and thus are reliable for diagnosing and follow-up in clinical practice.

Financial Disclosure:

NONE