Posters

Exacerbation of granular dystrophy after LASIK and anterior lamellar keratoplasty procedure

Poster Details

First Author: S. Nobacht NETHERLANDS

Co Author(s):                        

Abstract Details

Purpose:

Case reports: To describe the localization and the amount of the exacerbation of the Granular dystrophy after corneal surgeries in two patients

Setting:

Department of the Ophthalmology, Radboud University Medical Centre, Nijmegen, The Netherlands

Methods:

Patient 1: 52 years old man who underwent 10 years a go a myopic LASIK treatment on both eye’s with preexistent corneal opacities.Ophthalmic examination revealed multiple snowflake shaped opacities in the cornea of the both eye’s in the interface. Sequence analyse of the whole exon and interon of TGFBI revealed a heterogenous mutation on P.(ARG124His) which is typical for Granular dystrophy type2. Patient 2: A 53 years old female with a known Familiair Granular Dystrophy type 1 underwent a Anterior Lamellar Keratoplasty (ALK) on both eye's. One year after the operation some granular opacities returned in the interface.

Results:

Granular dystrophy of the cornea is an autosomal dominant disorder with a known mutation on TGFBI gen. Exacerbation of GD after lamellar or penetrating keratoplasty and after Excimer laser refractive surgery such as LASIK or PRK are already described in the literature. De exacerbation of these opacities after LASIK procedure are mostly located in the interface and are more central in the visual axis. Exacerbation of Granular Dystrophy after ALK procedure are more located in the transition zone graft/host and also in the interface

Conclusions:

In our opinion a LASIK procedure in the patients with Granular Dystrophy is contra-indicated because of severe exacerbation in the interface which mostly located centrally in the visual axis. Surgical treatment in these cases are very challenging and may be disappointing.

Financial Disclosure:

NONE