Posters
Clinical characterization of corneal features in Down's syndrome patients
Poster Details
First Author: A. Vega-Estrada SPAIN
Co Author(s): A. Osman P. Sanz Diez A. Kamal J. Alio
Abstract Details
Purpose:
To characterize the main features of the cornea in patients with Down syndrome.
Setting:
Vissum, Alicante, Spain. Division of Ophthalmology, Miguel Hernández University, Alicante, Spain. Faculty of medicine, Cairo University, Egypt. Pediatric hospital, Genetic clinic, Egypt.
Methods:
Prospective and multicentric study we included a total of 217 eyes of 110 patients with ages ranging from 60 to 1 year (mean age of 23.3 ± 13.8 years). All cases were divided into two groups according to the level of cooperation that had patients during eye examination. The cooperative group consisted in cases that underwent a full ocular examination, refraction, fundoscopic exam, topography, aberrometry examination and axial length measurement. The uncooperative group consisted in cases that who had a full ocular examination, refraction, fundoscopic exam but they were totally uncooperative to perform topography and aberrometry or axial length measurements.
Results:
123 cases from cooperative group and 94 cases from uncooperative group. 55 patients (50%) were men and two 55 patients (50%) women. The mean refractive spherical equivalent was -2.28±6.21 diopters. Mean keratometric values were 46.32±6.14 diopters in flat meridian and 49.63±8.05 diopters in steep meridian. Mean asphericity in a 4.5 mm diameter corneal area was -0.55±1.12, and mean asphericity in an 8.0 mm was -0.70±1.33. The axial length values were 24.97±1.98 mmHg. The intraocular pressure values were 14.64±3.20 mmHg. Analysis of coma-like corneal aberrometry showed 1.85±4.37 µm. In biomechanical data we observed CH = 9.95±0.91 and CRF = 8.75±1.62 mmHg.
Conclusions:
BThe effect that the presence of this genetic alteration causes in each person varies widely. In these cases a high prevalence of corneal disorders were found. The study a corneal features of Down syndrome patients is very important to have a greater knowledge of the behavior of corneal collagen in these patients.
Financial Disclosure:
NONE
