Posters

Effect of keratoconus severity and cone location in corneal diameter, anterior chamber depth and anterior chamber volume

Poster Details

First Author: S. Ortiz-Toquero SPAIN

Co Author(s):    V. de Juan   G. Rodriguez   D. Galarreta   R. Martin           

Abstract Details

Purpose:

Keratoconus is a corneal disorder progressive characterized by thinning and steepening of the central and paracentral cornea which leads to protrusion. Corneal topographic assessment in keratoconus is useful in diagnosis and monitoring progression, especially corneal thickness and corneal curvature. However, the effect of keratoconus progression or cone location in other anterior segment parameters, such us, corneal diameter (white-to-white distance; WTW), anterior chamber depth (ACD) or anterior chamber volume (ACV) has not been previously analyzed. The aim of this study was to assess the influence of keratoconus severity and cone location in corneal diameter, ACD and ACV comparing with healthy eyes.

Setting:

IOBA-Eye Institute, University of Valladolid (Valladolid, Spain).

Methods:

Corneal topography of 56 keratoconus eyes and 56 healthy eyes was assessed using Dual-Scheimpflug topography (Galilei-G4; Ziemer Group, Port, Switzerland). Healthy subjects involve corneas without any ocular surface alteration (allergy, dry eye, ulcer, scar or other) and keratoconus patients were diagnosis after a complete eye-examination. Keratoconus eyes were divided in severity stage of disease according to Amsler-Krumeich classification (n=26 Stage#1; n=21 Stage#2 and n=9 Stage#3) and cone location (n=38 central keratoconus, apex within central 2mm; n=18 non-central keratoconus, apex outside central 2mm). Corneal diameter (WTW, mm), ACD (from corneal endothelium to anterior lens Surface, mm) and ACV (mm3) were collected.

Results:

Healthy eyes showed greater values than keratoconus eyes in WTW (11.93±0.33 and 11.89±0.38, P=0.62), ACD (3.24±0.31 and 3.23±0.30, P=0.87) and ACV (154.52±27.14 and 141.66±30.45, P=0.03). No significant differences were found between severity stage#1, #2 and #3 in WTW (11.90±0.43, 11.89±0.27 and 11.89±0.52, P=0.97), ACD (3.26±0.30, 3.14±0.31 and 3.35±0.26, P=0.46) and ACV (145.92±36.94, 137.71±14.97 and 135.83±36.87, P=0.12). Moreover, no significant differences were found between central and non-central keratoconus in WTW (11.95±0.40 and 11.77±0.32, P=0.11), ACD (3.21±0.34 and 3.26±0.20, P=0.64) and ACV (142.75±29.33 and 139.33±33.65, P=0.73).

Conclusions:

These results suggest that corneal diameter, ACD and ACV are not affected by keratoconus severity stage or cone location. These results could be of importance to eye care practitioners and refractive surgeons to support clinical decisions and may also facilitate keratoconus patients’ assessment and follow up.

Financial Disclosure:

NONE