Posters

Therapeutic effect of amniotic membrane transplantation in paraquat-induced ocular surface injury: case reports

Poster Details

First Author: P. Lee TAIWAN

Co Author(s):                        

Abstract Details

Purpose:

Paraguat is an herbicide with dipyridylium quaternary ammonium salt as main content. It is extremely toxic to humans and may produce multiple organ failure. In contrast to systemic toxicity, treatment and prognosis of ocular surface toxicity are not well described. We report 2 patients with paraquat induced ocular surface injury, one treated successfully with medical treatment and the other received amniotic membrane transplantation and with well healed epithelium.

Setting:

It’s a retrospective case report.

Methods:

Clinical appearance and progress of bilateral ocular chemical injury caused by paraquat were recorded. One patients received amniotic membrane transplantation surgery and clinical results were analyzed

Results:

After a short course (5~7days) of medical treatment. One patient’s cornea and conjunctiva healed spontaneously(Figure 1, Case 1) but the other patient (figure 2, Case 2) had poor healing epithelial defect. Therefore, amniotic membrane (AM) grafting operation was arranged and covered to the ocular surface of lesion eye and sutured to the conjunctiva with 10-0 nylon. During this procedure, partial limbal conjunctiva tissue was excised for pathological report, and showed severe lymphocytic infiltration and disc ernible fibrosis. After operation, the conjunctival erosion started healing and pseudomambrane formation decreased. Corneal epithelial defect healed completely after removing AM graft, and without the development of conjunctivalization of the cornea

Conclusions:

Paraquat-induced ocular surface injury had a relatively good prognosis. Amniotic membrane has antiantiangiogenic, antiscarring, and anti-inflammatory properties. In our cases, it could be used as a graft for corneal and conjunctival reconstruction, and facilitate epithelialization and suppress inflammation in acute stage of chemical injury.

Financial Disclosure:

NONE