Posters

Tear osmolarity in ocular graft versus host disease

Poster Details

First Author: M. Cabanas SPAIN

Co Author(s):    A. Munoz-Morales   M. Caro-Magdaleno   J. Del Trigo Zamora   J. Sanchez Vicente   A. Alfaro Juarez   J. Montero     

Abstract Details

Purpose:

To asses the elevation of tear osmolarity in chronic ocular Graft Versus Host Disease

Setting:

Chronic ocular GVHD occurs in 40-60% patients with hematopoietic transplant. DES in the more frecuent complication. It is important to make a promnt diagnosis. Tear osmolarity can be a usefull tool for this patients.

Methods:

16 eyes of 8 patients affected by ocular cGVHD were evaluated with TearLab Osmolarity System (TearLab Corp, San Diego,CA). It was the first test done in the patient, between 9-10 am,without artificial teardrops at least 8 hours before examination. We measure osmolarity in 16 eyes of 8 healthy patients. Differences between both groups was made by statistical analysys using SPSS.

Results:

The mean +/- SD of tear osmolarity measure in the GVHD group was 312 +/- 4 mOsm/L and in the control group was 298 +/- 5 mOsm/L. Tear osmolarity significantly increases with severity of DES in GVHD. It was significantly higher in the GVHD group compaired with the control group.

Conclusions:

The results are in accordance with literature. Tear osmolarity can be a usefull tool to help in diagnose ocular GVHD from healthy eye. A test value higher from 308 mOsm/L is significantly correlate with DES in ocular GVHD.

Financial Disclosure:

NONE