Posters

DNA positive heterozygous GCD-1 diagnosed after PRK

Poster Details

First Author: M. Balidis GREECE

Co Author(s):    N. Dragoumis   D. Mikropoulos                 

Abstract Details

Purpose:

To present a previously undiagnosed familial case of stromal dystrophy (Granular Corneal Dystrophy Type I or GCD-1) detected postoperatively on a corneal graft.

Setting:

“Ophthalmica” private Eye Institute, Thessaloniki, Greece.

Methods:

A 38-year-old patient presented following a bilateral penetrating keratoplasty, with unclear ophthalmic history. Refractive correction and topographic data demonstrated high postoperative astigmatism in both eyes. The patient underwent PRK with mitomycin C bilaterally. 9 months post PRK, there were multiple bilateral whitish stellate and linear corneal opacities. AS-OCT revealed hyperreflective deposits within the anterior stroma in both eyes. After obtaining a family history, a first and second degree relative with an unknown eye condition were identified. They were subsequently examined and found to have a similar phenotype. DNA testing was positive in all three patients for heterozygous GCD-1.

Results:

A diagnosis of GCD-1 was established which in the initial patient manifested on the corneal graft after PRK was performed for high postoperative astigmatism.

Conclusions:

It is evident that PRK is responsible for accelerating the manifestation of GCD-1 or GCD-2. This is the first reported case of DNA positive heterozygous GCD-1, presented in three family members in Southeastern Europe.

Financial Disclosure:

NONE