Posters

Colored ophthalmic viscosurgical compositions containing a natural dye

Poster Details

First Author: D. Sousa Martins PORTUGAL

Co Author(s):    F. Louro   M. Monteiro                 

Abstract Details

Purpose:

Complications may arise from the use of ophthalmic viscosurgical devices (OVDs). Residual OVD left in the eye can lead to transient elevation in postoperative intraocular pressure. A colored OVD may be an advantage, since it could be distinguished from the surrounding structures and thus better monitored and removed.

Setting:

Efficacy of colored ophthalmic viscosurgical devices in ex vivo phacoemulsification.

Methods:

Colored OVDs were characterized based on their aspect, transparency, pH, osmolality and viscosity. Cadaveric pig eyes underwent phacoemulsification in the presence of the colored OVD prototypes under study, or a cohesive OVD comparator currently in the market. After each procedure, masked investigators completed a subjective questionnaire about OVD characteristics during each stage of the procedure. Objective safety parameters, such as intraocular pressure, were evaluated and histological observations of the tissue were performed to assess endothelial protection endowed by the product.

Results:

The OVDs showed a pseudoplastic behavior with low thixotropy. The natural dyes employed proved to be suitable for staining the viscoelastic, and their transparency was adequate. The dyes did not diffuse out of the polymeric matrix and into the surrounding tissue. The performance of the colored OVDs was adequate.

Conclusions:

The use of a colored OVD may prove an advantage over conventional OVDs, since the presence of color may facilitate the monitoring and removal of the viscoelastic, reducing the risk of post-operative complications. Results were promising, but further in vivo studies are needed to confirm this hypothesis.

Financial Disclosure:

One or more of the authors is employed by a forNONEprofit company with an interest in the subject of the presentation