A new hyperspectral imaging method to evaluate dry eye syndrome

Session Details

Session Title: Cornea Medical II

Session Date/Time: Tuesday 13/09/2016 | 08:00-10:30

Paper Time: 09:18

Venue: Hall C3

First Author: : F.Segev ISRAEL

Co Author(s): :    N. Gefen   L. Suh   D. Trief   Y. Cohen   R. Gefen   A. Harris     

Abstract Details

Purpose:

Dry eye syndrome (DES) is a multi-factorial condition that is difficult to diagnose, in part due the inconsistent results of objective testing methodologies. The study purpose was to evaluate the Tear Film Imager (TFI), a novel testing methodology using three dimensional white light tomography (3D-WLT), to measure key parameters of tear film composition that are abnormal in the dry eye state

Setting:

General Hospital

Methods:

: DES severity was graded using conventional DES testing methods, including: Schirmer test, tear breakup time (TBUT), tear meniscus height, corneal fluorescein staining and a patient questionnaire. Subsequently, each patient underwent a two-minute TFI test followed by a retest after 30 minutes. The TFI measures the aqueous layer thickness (ALT) at a nanometer level and calculates average ALT as well as the ALT rate. In addition, the TFI measures the lipid layer thickness (LLT) at a sub-nanometer level and establishes average LLT and lipid breakup time (LBUT)

Results:

33 subjects were included. DES severity clinical grading was as follows: 16 severe, 7 mild and 10 controls. The TFI quantitative measurements diagnosed DES subjects with 96% sensitivity and 70% specificity. The TFI LBUT measurement correlated well (Pearson 0.93, p<0.01) to TBUT and distinguished lipid from aqueous layer abnormalities. The TFI ALT measurements were highly agreeable (Pearson 0.89, p<0.01) between the two measurements and clearly distinguished aqueous tear deficiency patients. The TFI ALT rate measurements demonstrated notable differentiation between the DES subjects and distinguished the presence of evaporative dry eye conditions

Conclusions:

TFI results demonstrated good agreement with traditional but less objective diagnostic methodologies, doing so in a fast, noninvasive manner. The TFI may be able to distinguish different etiologies of DES using quantifiable data and to monitor treatment effectiveness

Financial Disclosure:

... gains financially from product or procedure presented, ... receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented