Dry eye parameter changes after corneal collagen cross-linking (CXL) with epithelium off for progressive keratoconus

Session Details

Session Title: Cornea Medical I

Session Date/Time: Monday 12/09/2016 | 17:00-18:30

Paper Time: 18:18

Venue: Hall C2

First Author: : G.Sahin TURKEY

Co Author(s): :    E. Sogutlu Sari   A. Yazici   K. Tinc   S. Ermis           

Abstract Details

Purpose:

To evaluate the effect of corneal collagen cross-linking (CLX) treatment on Schirmer score, tear break-up time (TBUT), tear osmolarity and ocular surface vital dye staining scores in progressive keratoconus patients

Setting:

Prospective and observational study. Balıkesir University Medical Faculty, Ophthalmology Department

Methods:

Eleven eyes of 7 progressive keratoconus patients were included. Schirmer test, T-BUT, Ocular Surface Disease Index (OSDI), Oxford grading, tear osmolarity test were done for each individuals before and 3rd day, 1st week and 1th month after CLX. All patients have received the same medical treatment during a month including antibiotic, steroid and artifical tear drops. All data were compared statistically .

Results:

The mean Schirmer test was 9.64±4.75milimeter (mm)before treatment and19.27±6,2 mm at 3rdday,13.73±8.46mm at1st week and 15.36±9.08mm at 1thmonth (p:0.005; 0.102; 0.045; respectively). The mean tear osmolarity was 289.09±15.85microliter(µlt) before treatment,304.09±6.17µlt at 3rdday, 300.82±11.38µlt at 1thweek and304.45±11.43 µlt at 1thmonth (p:0.202; 0.594; 0.349; respectively).The mean T-BUT was 10.45±3.44 second(sec) before treatment and 9.55±3.83sec at 3rdday, 12.45±6.93 sec at 1stweek, 15.09±4 86sec at 1thmonth (p:0.812; 0.192; 0.061; respectively).The mean Oxford grading score was 0, 2.45±0.82, 0.82±0.60, 0.18±0.60(p:0.003; 0.007; 0.317;respectively). The OSDI score was 2.08±4.65 before treatment, 21.63±20.03 at 3rdday, 25.47±25.86 at 1thweek, 11.05±31.42 at 1stmonth (p:0.015; 0.012; 0.273: respectively)

Conclusions:

Tear osmolarity did not significantly impair after CLX , however statistically significant change was observed for Schirmer test, T-BUT and Oxford score during the short follow-up. We suggest that patients after corneal cross-linking be screened for dry eye syndrome and probably treated long-term for a prevention of ocular surface damage. Further large scaled studies are needed to reach a better conclusion.

Financial Disclosure:

NONE