Clinical profile of early keratoconus with normal vision-based on pattern recognition analysis

Session Details

Session Title: Keratoconus and Phakic IOLs

Session Date/Time: Monday 12/09/2016 | 16:30-18:30

Paper Time: 16:42

Venue: Hall C4

First Author: : J.Alio SPAIN

Co Author(s): :    P. Sanz Diez   M. Prieto   A. Vega-Estrada   A. Cardona   M. Maldonado   R. Gutierrez     

Abstract Details

Purpose:

To characterize the pattern that offer the keratoconus cornea with normal vision in which is to the best of our knowledge the largest sample reported of early keratoconus confirmed cases, homogeneously studied, and makes them different from a normal control group.

Setting:

Vissum Alicante, Spain

Methods:

Prospective multicentrical observational comparative study. It includes a total of 995 eyes divided in two groups: Early keratoconus group with normal visual acuity (keratoconus grade I of the RETICS classification) and control group (normal eyes). The keratoconus group consisted in eyes with early forms of keratoconus defined as those cases with a spectacle-corrected distance visual acuity (CDVA) ≥ 0.9. To perform a pattern recognition analysis, the combination of two statistical methods principal components analysis (PCA) and discriminant analysis was performed.

Results:

625 eyes from early keratoconus group (62.8%) with mean age of 36.07 ± 10.54 years and 370 eyes from control group (37.2%) with mean age of 34.21 ± 7.18 years was studied. No statistically significant differences between the study groups were observed in the age variable (p>0.05). Applying the PCA with Varimax rotation, a total of 5 factors are generated, which explains the 85.51% of the total variability. Discriminant analysis indicates that factors 1 and 3 are at the greatest discriminating capacity. From a total of 318 cases, 275 were correctly classified from both study groups, representing 86.50% success.

Conclusions:

The variables of corneal shape and profile and the variables that refer to the visual and refractive condition are those that best characterize and differentiate the groups studied. The analysis of the evolution of the pattern profile found here as associated to normal vision in early keratoconus cases may be also related to the progression in the severity of the disease and may reveal in further investigations unveiled associations related to the prognosis of visual loss.

Financial Disclosure:

NONE