Evaluation of lamina cribrosa and choroid in nonglaucomatous patients with pseudoexfoliation syndrome using spectral-domain OCT

Session Details

Session Title: Glaucoma II

Session Date/Time: Monday 12/09/2016 | 08:00-10:30

Paper Time: 08:46

Venue: Hall C4

First Author: : M.Mazloumi IRAN

Co Author(s): :    S. Moghimi   M. Johari   G. Fakhraie   M. Mohammadi   R. Zarei   S. Lin     

Abstract Details

Purpose:

To evaluate lamina cribrosa (LC) and macular/peripapillary choroid in patients with pseudoexfoliation syndrome (PXS).

Setting:

Cross-sectional observational study.

Methods:

One eye of 38 non-glaucomatous PXS cases and 37 healthy volunteers were enrolled in the Glaucoma clinic of Farabi Eye Hospital. The optic discs and macula were scanned using enhanced depth imaging spectral domain optical coherence tomography and measurements were obtained using HEYEX software 6.0 (Spectralis OCT, Heidelberg Engineering, Heidelberg, Germany). Lamina cribrosa and other related variables at 3 areas (mid superior, center, and mid inferior) and choroidal thickness in the peripapillary area and ETDRS zones of the macula were determined. Linear mixed modeling was used to adjust the variables. Interclass coefficient correlation (ICC)l was calculated.

Results:

There was neither significant difference in peripapillary choroidal thickness nor in retinal nerve fiber layer thickness between the two groups. The LC was significantly thinner at all 3 areas in the PXS group compared to the control group. While no significant difference in central laminar depth was observed between two groups (p=0.74), the superior and inferior laminar depth were significantly deeper in the PXS group (380.0±81.51 and 350.82±99.73, respectively) compared to the control group (324.05±87.68 and 280.33±92.38, respectively) (p=0.04 and p=0.006, respectively). While there was significant negative correlation between age and central choroidal thickness in the control group (r= -0.48, p=0.01), this correlation was not significant in the PXS group (r=-0.08, p=0.68).

Conclusions:

We found that LC is significantly thinner in all three areas of the ONH in non-glaucomatous PXS patients than in controls. While no significant difference in central ALD was observed between the two groups, peripheral posterior displacement of LC in non-glaucomatous PXS eyes was noted. Choroidal thickness is not thinner in PXS patients compared to controls.

Financial Disclosure:

NONE