Session Title: Cornea
Session Date/Time: Sunday 17/02/2013 | 08:30-11:00
Paper Time: 08:48
Venue: Hall 2
First Author: : A.El Shiaty EGYPT
Co Author(s): : H. Gabr E. Darwish
Purpose:
An intervention case series demonstrating the use of mesenchymal stem cells ex-vivo co-cultured with limbal tissue in the management of limbal stem cell deficiency.
Setting:
Kasr ElAini Faculty of Medicine, Departments of Ophthalmology and Clinical Pathology, Cairo University, Cairo, Egypt.
Methods:
Eight eyes of seven patients suffering from limbal stem cell deficiency were treated with mesenchymal stem cells derived from their own bone marrow. The mesenchymal stem cells had been co-cultured with allolimbal tissue and transplanted to the patient limbus after being carried on an amniotic membrane.
Results:
The stem cell deficiency was improved initially in all patients. Recurrence of stem cell deficiency occurred by different degrees in four patients. The follow up period ranged from 3 to 22 months.
Conclusions:
Mesenchymal stem cell transplantation may be helpful in management of limbal stem cell deficiency when sufficient limbal stem cells are not available.
Financial Disclosure:
None
