Session Title: Cornea
Session Date/Time: Sunday 17/02/2013 | 08:30-11:00
Paper Time: 08:42
Venue: Hall 2
First Author: : S.Lee SOUTH KOREA
Co Author(s): : C. Cho J. Lee
Purpose:
To investigate clinical characteristics, causative microorganisms, and in vitro antibiotics susceptibility of bacterial isolates for patients with contact lens-related bacterial keratitis.
Setting:
Yeungnam University Hospital, Daegu, South Korea.
Methods:
Seventy three patients with contact lens-related bacterial keratitis inpatients hospitalized at Yeungnam University Hospital between January 1998 and December 2011 were reviewed retrospectively. Their clinical characteristics, bacteriological profiles and in vitro antibiotics susceptibility were evaluated.
Results:
Female with third-decade (35 eyes, 47.9%) was the common sex/age group and the common predisposing factor was sleeping with their contact lenses in (30 eyes, 41.1%). Positive culture rate was 53.4% (39/73). The ratio of gram-positive/negative bacteria was 8.3% : 91.6% (4:44). The commonly isolated microorganisms were Pseudomonas spp. (39.6%, 19/48), followed by Serratia spp. (29.2%, 14/48), and Enterobacter spp. (10.4%, 5/48). The characteristics of corneal lesion were central in 49 eyes (67.1%), size less than 5mm² in 54 eyes (74%), and hypopyon in 8 eyes (11.0%). Mean epithelial healing time was 7.7 ± 3.9 days. The mean logMAR BCVA was improved from 0.93±0.88 at the initial visit to 0.25 ± 0.48 at the final visit. Antibiotics exhibiting high susceptibility for gram-negative bacteria were meropenem (100.0%), levofloxacin (100.0%), imipenem (97.7%), ceftazidime (95.5%), and ciprofloxacin (94.7%). BCVA less than 0.1 at initial visit was found as risk factor for poor visual outcome (less than BCVA 0.3) after remission medical treatment.
Conclusions:
Pseudomonas spp. and Serratia spp. were the common bacterial isolates in contact lens-related bacterial keratitis. Levofloxacin, ceftazidime, and ciprofloxacin exhibited excellent antibiotic susceptibility for gram-negative bacterial isolates in contact lens-related bacterial keratitis. These findings have important public health implications for the selection of antibiotics for contact lens-related bacterial keratitis.
Financial Disclosure:
None
