Posters

Comparative analysis of the drugs for substitution therapy of the dry eye syndrome in Ukraine and Great Britain

Poster Details

First Author: O.Kryvoviaz UKRAINE

Co Author(s): S. Kryvoviaz   Y. Tomashevska                 

Abstract Details

Purpose:

Managing patients with the dry eye syndrome is complex and involves the use of both conservative and surgical techniques. The treatment is aimed at reducing the deficiency of the lacrimal fluid and stabilizing the lacrimal film. The dry eye syndrome treatment depending on the etiological factors and severity of the disease usually begins with over-the-counter tear substitutes in the early stages. Therefore, the purpose of the research is to analyze the composition and medicinal forms of drugs for substitution therapy of dry eye syndrome that are available on the pharmaceutical market of Ukraine and Great Britain.

Setting:

S01X A20 group drugs compositions – “Artificial tear fluid substitutes and other neutral drugs” according to the State Register of Medicines of Ukraine (2019) as well as of the ocular lubricants according to the British National Formulary 76 (September 2018 – March 2019) were analyzed and compared.

Methods:

The analysis of information was carried out by marketing, statistical, structural and graphic methods. First the information array of drugs for treating dry eye syndrome was formed by the analysis of official sources data. The segmentation according to the Anatomical-therapeutic-chemical classification was carried out during the structural analysis of the assortment of drugs. Next, a structural analysis of the assortment of drugs by INN was carried out. The segmentation of drugs assortment by composition and type of medicinal forms has also been performed.

Results:

There are 7 compositions of drugs active ingredients of the S01X A20 group – “Artificial tear fluid substitutes and other neutral drugs” for local substitutive therapy for dry eye syndrome in Ukraine. At the same time the group “Ocular lubricants” includes 15 compositions in Great Britain. An analysis of the drugs forms for substitution therapy showed that in Ukraine they are presented in two forms: eye drops and eye gels. Assortment analysis of ocular lubricants that are registered in Great Britain showed also the presence of eye ointments.

Conclusions:

The mechanism of action of drugs for substitution therapy of the dry eye syndrome in both countries is provided by the presence of active ingredients such as sodium hyaluronate, carbomer, hypromellose, carmellose, polyvinyl alcohol. Polyquad and povidone are used only in Ukraine. There are also acetylcysteine, hydroxyethylcellulose, sodium chloride, soybean oil, sodium hyaluronate with trehalose, hydroxypropyl guar with polyethylene glycol and propylene glycol, hypromellose with dextran 70, different combinations of paraffin that are registered in the composition of ocular lubricants in Great Britain that are not required in artificial tear fluid substitutes and other neutral drugs in Ukraine.

Financial Disclosure:

None