Posters

0.1% glucose vs BSS infusion during DMEK surgery: a double-blind comparative prospective study

Poster Details

First Author: P.Viola ITALY

Co Author(s): E. Neri   R. Cian   A. Iovieno   S. Soldati           

Abstract Details

Purpose:

considering physiological high glucose-consumption of endothelial cells and glucose wash-out by basal salt solution (BSS) during surgery, the purpose of this study is to determine if infusing 0.1% glucose solution during Descemet membrane endothelial keratoplasty (DMEK) determines different early results or rebubbling rate compared to BSS infusion.

Setting:

San Bortolo Hospital, Vicenza (Italy). All surgeries were performed by the one surgeon (PV)

Methods:

this was a double-blind comparative study of 20 eyes (10 couples) of different patients undergoing DMEK to treat Fuchs dystrophy or bullous keratopathy. Each couple affected by the same pathology received the pre-loaded endothelium-in-graft from the same donor the same day. One eye underwent DMEK with infusion of 0.1% glucose solution (group-1), the other eye with BSS solution (group-2). Main outcome measures were rebubbling rate, distance-corrected visual acuity (CDVA), its recovery rate (difference between 1 and 3 months, DVA), central corneal thickness (CCT), its difference between 1 and 3 months (DCCT), endothelial cell loss (ECL) within 1 and 3 months.

Results:

rebubbling rate was the same in the two groups (20%).Average CDVA was similar in the two groups (0.20 logMAR and 0.16 logMAR at 1 month, (p=0.564); 0.16 logMAR and 0.04 logMAR at 3 months, respectively (p=0,257).Mean DVA was 0.04 and 0.16 (p=0.194).Mean 1-month CCT was: 547mm and 540mm respectively (p=0.715); at 3 months 559mm and 548mm, respectively (p=0.893).DCCT was 26.83mm in group-1 and 13.5mm in group-2 (p=0.968).Similarly, average 1-month and 3-month ECL did not differ significantly between groups (22% and 32% at 1 month, p=0.285; 31% and 36% at 3 month (p=0.465), respectively).

Conclusions:

the results of group with 0.1% glucose solution were similar to group with BSS solution, suggesting that the composition of infusion during the surgery do not affect rebubbling rate and morphological or functional outcomes in DMEK, even if low sample size does not let to draw definitive conclusions.

Financial Disclosure:

None