Posters

The evaluation of long term results of effectiveness and safety of standard and accelerated corneal cross-linking in patients with progressing keratoconus at different corneal thickness

Poster Details

First Author: I.Vasilyeva RUSSIA

Co Author(s): V. Egorov   A. Vasilyev   A. Egorova              

Abstract Details

Purpose:

To study the effectiveness and safety of standard and modified accelerated corneal crosslinking (CLX) in patients with keratoconus (K) at various initial values of deepithelized central cornea thickness (CCT).

Setting:

The work was performed in the Khabarovsk branch of the Federal State Autonomous Institution «S.N. Fedorov National Medical Research Center «MNTK «Eye Microsurgery» of the Ministry of Health of the Russia.

Methods:

74 patients (74 eyes) with progressing K stages 1 and 2 were examined and divided into 2 groups depending upon parameters of UV light. Patients of the first group underwent standard CXL, of the second – accelerated (15 minutes with power of 6 mW/cm²). All patients were additionally divided into two subgroups according to minimal values of deepithelized CCT. First subgroup of each group - CCT from 400 to 450 microns, the second – more than 450 microns. UCVA, BCVA, Kmax, keratopachymetry, CCT and endothelial cells density were evaluated preoperatively and one-year postoptoperatively. Corneal haze was also examined at biomicroscopy.

Results:

None of patients had K progression. Mean values of Kmax decreased in all subgroups. The effect of corneal “flattering” was more significant in patients in both groups with deepithelized CCT less than 450 microns. The maximal effect of corneal “flattering”, observed at standard CLX in eyes with CCT less than 450 microns, made 2,89±1,11 D. The lowest – at accelerated CLX in eyes with CCT more than 450 microns (mean 0,89±0,31 D). However, at standard CLX in eyes with CCT less than 450 microns two cases of late-onset corneal haze were noticed. Other values had no significant subgroup discrepancies.

Conclusions:

Performed analysis showed that both standard and accelerated CLX are effective in keratoconus stabilization no matter what initial values CCT were. The greatest effect of corneal flattering was achieved at standard method. Carrying out of standard CLX in patients with CCT less than 450 microns can induce late-onset corneal haze, causing decrease of vision acuity.

Financial Disclosure:

None